He was born on May 15, 1959 in New York. He is a US film producer.
He began his career at Walt Disney Pictures as executive producer of the live-action comedy Cool Runnings - four sub-zero. After this experience he moved to the 20th Century Fox Animation, where he worked in particular in animation cinema. His work is done at Blue Sky Studios, owned by Fox. Here he supervises and produces some of the studios' greatest hits such as Ice Age, Ice Age 2, Robots and Horton Hears a Who!.
In 2007 he left the Blue Sky and founded the animation studios Illumination Entertainment, owned by Universal Pictures, still active on animated films and live mixed films -action and animations.
In 2016 the giant NBC Universal acquires the studios DreamWorks Animation and Meledandri become in charge of both animation studios.